Development Pipeline
LSO is focusing on three cancers for the initial development of Litx™: Hepatoma, Metastatic Colorectal Cancer and Glioma.
Current Clinical Trials
Phase III trials are underway in hepatocellular carcinoma and colorectal cancer metastatic to the liver.
Publications
- Christophersen J, Winship MJ, Keltner L, Wang SS: Light-activated drug therapy in canine prostate. 2008 ASCO Annual Meeting. J Clin Oncol. May 20 suppl; abstr 14671.
- Kujundzic M, Vogl TJ, Stimac D, Rustemovic N, Hsi RA, Roh M, et al. A Phase II safety and effect on time to tumor progression study of intratumoral light infusion technology using talaporfin sodium in patients with metastatic colorectal cancer. J Surg Oncol 2007;96(6):518-24.
- Winship MJ, Wang S-S, Chen JC, Keltner L, Christophersen JS: Treatment of colorectal liver metastases using talaporfin sodium and intratumoral placement of LEDs. 2005 ASCO Annual Meeting 2005; 23 (16s, Part I of II):286s (abstract 3663).
- Xu H, Liang Y, Krouse M, Kylstra JW, Winship J, Chen JC, et al.: Ablation of liver tumors with novel light activated drug-device technology (Litx): Targeting feeding vessels may permit killing of larger tumor volumes. Gastrointestinal Cancers Symposium 2005:143 (poster abstract 21).
- Lustig RA, Vogl TJ, Fromm D, Cuenca R, Alex Hsi R, D'Cruz AK, Krajina Z, Turic M, Singhal A, Chen JC. A multicenter Phase I safety study of intratumoral photoactivation of talaporfin sodium in patients with refractory solid tumors. Cancer 2003;98(8):1767-71.
- Chen J, Keltner L, Christophersen J, Zheng F, Krouse M, Singhal A, et al. New technology for deep light distribution in tissue for phototherapy. Cancer J 2002;8(2):154-163.
- Zheng FC, Krouse M, Christophersen J, Chen J, Wang S, Huston D, et al.PDT using a novel LED light source and LS11 in a rat liver model. 30th Annual Meeting of the American Society for Photobiology; 2002 13-17 July; Quebec City, Canada. American Society for Photobiology: 33 [abstract 95]